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Bioorg Med Chem Lett. 2002 Jan 7;12(1):5-8.

Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.

Author information

1
Inpharzam Ricerche, Zambon Group, Via Ai Soi, 6807, Taverne, Switzerland. mauro.napoletano@zambongroup.com

Abstract

This communication describes the synthesis and in vitro evaluation of a novel and potent series of phthalazine phosphodiesterase type (IV) (PDE4) inhibitors. The interaction with two distinct polar binding sites allowed us to eliminate the cyclopentyloxy substitution from rolipram-like analogues.

PMID:
11738561
DOI:
10.1016/s0960-894x(01)00668-0
[Indexed for MEDLINE]

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