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Curr Opin Chem Biol. 2001 Dec;5(6):654-9.

Protein-protein interfaces: mimics and inhibitors.

Author information

1
Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. andrea@gene.com

Abstract

Many biological processes are mediated by specific molecular recognition between proteins. However, the thermodynamic and structural 'rules' for such recognition are incompletely understood, as is the potential for inhibition by small molecules. Recent progress has included the discovery of small-molecule inhibitors for several targets important in cancer.

PMID:
11738175
DOI:
10.1016/s1367-5931(01)00262-9
[Indexed for MEDLINE]

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