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Br J Surg. 2001 Dec;88(12):1558-69.

Immune therapy in inflammatory bowel disease and models of colitis.

Author information

1
Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK. baljit.singh@nds.ox.ac.uk

Abstract

BACKGROUND:

A proliferation of animal models has not only improved our understanding of inflammatory bowel disease, it has also formed the basis of new treatment strategies.

METHODS:

A search was conducted using the National Library of Medicine for articles discussing immune therapies for inflammatory bowel disease. This was supplemented by findings from the authors' own laboratory.

RESULTS:

An overview of the different animal models is presented. These models are used to highlight the recent human trials of immune therapies. Potential future therapies are also discussed.

CONCLUSION:

Immune therapies have altered the management of patients with inflammatory bowel disease. In future they will influence not only the indications for surgery but also its timing and outcome.

[Indexed for MEDLINE]

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