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Br J Clin Pharmacol. 2001 Dec;52(6):708-10.

Excretion of low molecular weight heparin in human milk.

Author information

1
Department of Gynaecology, Benjamin Franklin University Hospital, Berlin, Germany. richter.c@gmx.de

Abstract

AIMS:

The excretion of low molecular weight heparin (LMWH) in breast milk was investigated in 15 lactating mothers after Caesarean section.

METHODS:

Blood and milk samples were collected before and 3-4 h after once daily routine subcutaneous injection of 2500 IU dalteparin. Anti-Xa activity was measured by an assay utilizing prolonged clotting times in plasma or breast milk as an index of LMWH activity.

RESULTS:

Plasma anti-Xa activities ranged from 0.074 to 0.308 IU ml(-1) of plasma. Anti-Xa activities in breast milk ranged from < 0.005-0.037 IU ml(-1) of milk. This is equivalent to a milk/plasma ratio of < 0.025-0.224.

CONCLUSIONS:

Therefore, it appears highly unlikely that puerperal thromboprophylaxis with LMWH has any clinically relevant effect on the nursing infant.

PMID:
11736885
PMCID:
PMC2014571
[Indexed for MEDLINE]
Free PMC Article

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