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Br J Clin Pharmacol. 2001 Nov;52(5):587-95.

Herb-drug interactions: review and assessment of report reliability.

Author information

1
Department of Health Care Sciences, George Washington University of Medicine, 2150 Pennsylvania Avenue N.W. #2B417, Washington, DC 20037, USA.

Erratum in

  • Br J Clin Pharmacol 2002 Apr;53(4):449P.

Abstract

AIMS:

The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs.

METHODS:

Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated using a scoring system for interaction probability.

RESULTS:

One hundred and eight cases of suspected interactions were found. 68.5% were classified as 'unable to be evaluated', 13% as 'well-documented' and 18.5% as 'possible' interactions. Warfarin was the most common drug (18 cases) and St John's wort the most common herb (54 cases) involved.

CONCLUSION:

Herb-drug interactions undoubtedly do occur and may put individuals at risk. However our present knowledge is incomplete and more research is urgently needed.

PMID:
11736868
PMCID:
PMC2014604
DOI:
10.1046/j.0306-5251.2001.01469.x
[Indexed for MEDLINE]
Free PMC Article

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