Send to

Choose Destination
Biochemistry (Mosc). 2001 Oct;66(10):1086-97.

Respiratory complex I: structure, redox components, and possible mechanisms of energy transduction.

Author information

Department of Biochemistry, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia.


Structural arrangements and properties of redox components of the mitochondrial and bacterial proton-translocating NADH:quinone oxidoreductases are briefly described. A model for the mechanism of proton translocation at first coupling site, which emphasizes participation of specifically Complex I-associated ubisemiquinones, is discussed. An alternative mechanism is proposed where all redox reactions take place in a hydrophilic part of the enzyme and the free energy accumulated as conformational constraint drives the proton pump associated with the hydrophobic polypeptides.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Biochemistry (Moscow)
Loading ...
Support Center