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Semin Cell Dev Biol. 2001 Dec;12(6):475-84.

Mammalian homologues of the Drosophila eye specification genes.

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Medical Genetics Section, Department of Medical Sciences, Edinburgh University, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.


The Drosophila compound eye is specified by the simultaneous and interdependent activity of transcriptional regulatory genes from four families: PAX6 (eyeless, twin of eyeless, eyegone), EYA (eyes absent), SIX (sine oculis, Optix) and DACH (dachshund). Mammals have homologues of all these genes, and many of them are expressed in the embryonic or adult eye, but the functional relationships between them are currently much less clear than in Drosophila. Nevertheless, mutations in the mammalian genes highlight their requirement both within and outside the eye in embryos and adults, and emphasize that they can be deployed in many different contexts.

[Indexed for MEDLINE]

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