Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2001 Dec 14;289(4):791-5.

Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia.

Author information

1
Department of Pharmacology and Neurobiology, Tokyo Medical and Dental University, Tokyo, Japan.

Abstract

To investigate the functional role of Ca(v)2.3 channel in glucose homeostasis, we performed in vivo glucose tolerance and insulin tolerance tests together with stress-induced glucose release tests using mice deficient in Ca(v)2.3 channel (Ca(v)2.3-/-). The Ca(v)2.3-/- mice were significantly heavier than wild-type mice. In glucose tolerance and insulin tolerance tests, Ca(v)2.3-/- mice showed a significantly higher blood glucose level compared to wild-type mice. However, stress-induced blood glucose changes in Ca(v)2.3-/- mice were similar to those in wild-type mice. These results suggest that Ca(v)2.3 channel plays a role in glucose homeostasis by reducing insulin sensitivity and that Ca(v)2.3-/- mice exhibit symptoms resembling non-insulin-dependent diabetes mellitus.

PMID:
11735114
DOI:
10.1006/bbrc.2001.6051
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center