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Trends Mol Med. 2001 Dec;7(12):542-7.

The molecular basis and potential role of survivin in cancer diagnosis and therapy.

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Boyer Center for Molecular Medicine, Dept of Pathology, Yale University School of Medicine, 295 Congress Avenue,., New Haven, CT 06536, USA.


Despite its genetic complexity and multifactoriality, two processes appear almost universally compromised in cancer: the control of cell proliferation and the regulation of cell lifespan. Survivin is a recently described molecule that has been implicated in both processes, and is overexpressed in most human cancers. The exploitation of the survivin signaling pathway might provide important predictive and prognostic clues in cancer diagnosis, and offer new therapeutic alternatives for cancer treatment.

[Indexed for MEDLINE]

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