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Br J Psychiatry. 2001 Dec;179:519-22.

Spontaneous lapses in dosing during chronic treatment with selective serotonin reuptake inhibitors.

Author information

1
Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, The Netherlands. W.E.E.Meijer@pharm.uu.nl

Abstract

BACKGROUND:

In previous research, lapses in dosing of paroxetine or sertraline were associated with significantly more discontinuation symptoms and deterioration of depressive symptomatology compared with fluoxetine.

AIMS:

To evaluate dosing lapses in patients chronically treated with selective serotonin reuptake inhibitors (SSRIs) in uncontrolled circumstances.

METHOD:

In a prospective observational study we evaluated compliance data in chronic users of SSRIs using electronic drug exposure monitors.

RESULTS:

During a 3-month follow-up we found that 50/69 (72.5%) patients missed at least one dosing day and 20/69 (29.0%) missed two or more consecutive days.

CONCLUSIONS:

About 30% of patients treated with short-acting SSRIs had dosing lapses of 2 or more days, which, as described in prior studies, is long enough to result in clinically relevant deterioration of mental status.

PMID:
11731355
[Indexed for MEDLINE]
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