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Curr Opin Microbiol. 2001 Dec;4(6):703-12.

Modular complexes that regulate actin assembly in budding yeast.

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Rosenstiel Medical Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA.


The actin cytoskeleton of budding yeast contains an extensive set of actin-associated proteins with conserved mammalian counterparts. For more than 20 years, yeast has been used as a model organism to dissect the in vivo functions of these factors, revealing an intricate web of genetic interactions in the cell. Now, a surge of biochemical reports is defining the physical interactions and activities of these proteins and providing mechanistic insights into their cellular roles. The emerging view is that most actin-associated proteins do not act alone but, rather, associate to form modular protein complexes that regulate actin assembly and organization.

[Indexed for MEDLINE]

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