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Fertil Steril. 2001 Dec;76(6):1150-6.

Assessment of early cleaving in vitro fertilized human embryos at the 2-cell stage before transfer improves embryo selection.

Author information

1
Assisted Conception Unit, Birmingham Women's Hospital, Edgbaston, Birmingham, United Kingdom. Denny.Sakkas@yale.edu

Abstract

OBJECTIVE:

To determine the most viable embryos for transfer.

DESIGN:

Study 1: Preselection of early-cleaving 2-cell embryos for transfer. Study 2: Alternating weeks during which preselection was performed and not performed.

SETTING:

ART program, Birmingham Women's Hospital, Birmingham, United Kingdom.

PATIENT(S):

Patients undergoing IVF or ICSI cycles with transfer on day 2.

INTERVENTION(S):

Culture of all fertilized embryos.

MAIN OUTCOME MEASURE(S):

Number of fertilized embryos cleaving to the 2-cell stage on day 1, embryo quality, implantation rates, and pregnancy rates.

RESULT(S):

Patients with early-cleaving 2-cell embryos had significantly higher pregnancy and implantation rates (45 of 100 [45.0%] and 58 of 219 [25.5%], respectively) than did patients without early-cleaving 2-cell embryos (31 of 130 [23.8%] and 43 of 290 [14.8%], respectively). In weeks during which preselection was used, the overall pregnancy and implantation rates of the clinic improved.

CONCLUSION(S):

The presence of early-cleaving 2-cell embryos improves a patient's chance of achieving pregnancy. Use of more stringent embryo selection criteria can improve overall pregnancy rates.

PMID:
11730743
[Indexed for MEDLINE]

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