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Am J Psychiatry. 2001 Dec;158(12):2083-5.

Cortisol feedback during the HPA quiescent period in patients with major depression.

Author information

1
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. posenerj@medicine.wustl.edu

Abstract

OBJECTIVE:

The authors tested the hypothesis that patients with major depression have a defect in the mechanism by which cortisol exerts negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis during the HPA axis quiescent period.

METHOD:

Twenty-nine patients with major depression and 25 healthy comparison subjects were randomly assigned to administration of 15 mg cortisol or placebo infused over 2 hours beginning at 7:00 p.m. Cortisol and ACTH levels were measured at baseline and every 30 minutes from 7:30 p.m. to 11:00 p.m.

RESULTS:

Differences between the patients and the comparison subjects in the ACTH response to the cortisol infusion, relative to the ACTH response to placebo, were not found.

CONCLUSIONS:

The results provide some evidence that patients with major depression do not have an abnormality of cortisol feedback during the HPA axis quiescent period.

PMID:
11729034
DOI:
10.1176/appi.ajp.158.12.2083
[Indexed for MEDLINE]
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