Format

Send to

Choose Destination
Nat Genet. 2001 Dec;29(4):375-6.

Conjugation between bacterial and mammalian cells.

Author information

1
Department of Medicine, School of Medicine University of California, San Diego, La Jolla, California 92093-0640, USA. vwaters@ucsd.edu

Abstract

Bacterial conjugation, in which DNA is transferred from one bacterium to another, was first reported in 1946 and found to be mediated by the F factor. Although the F and RK2/RP4 prototypic plasmids can mediate the transfer of DNA from bacteria to yeast, there has been no evidence of classical bacterial conjugation to higher eukaryotes. Here, I present evidence of such transfer, using Escherichia coli, the RK2 plasmid system and Chinese hamster ovary CHO K1 cells.

PMID:
11726922
DOI:
10.1038/ng779
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center