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Neuroreport. 2001 Dec 4;12(17):3759-61.

A new locus on chromosome 19 linked with late-onset Alzheimer's disease.

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  • 1Division of Neurology, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430, USA.


Alzheimer's disease (AD) is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. APOE 4 and APOCI A on chromosome 19 are risk factors for late-onset disease. Using large extended families with multiple siblings affected, we have identified several microsatellite markers which are also linked with late- onset Alzheimer's disease. These microsatellites are distal from the apolipoprotein cluster on chromosome 19. It is likely that multiple genes will be involved with late-onset disease, either as risk factors or as causative agents.

[PubMed - indexed for MEDLINE]
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