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Nat Immunol. 2001 Dec;2(12):1109-16.

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.

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1
Division of Immunology and Allergy, Department of Pediatrics and the Howard Hughes Institute, Stanford University, Stanford, CA 94305-5208, USA.

Abstract

To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy.

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PMID:
11725301
DOI:
10.1038/ni739
[Indexed for MEDLINE]

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