Huntington's disease

Mol Pathol. 2001 Dec;54(6):409-13. doi: 10.1136/mp.54.6.409.

Abstract

The most recent findings in the elucidation of the molecular pathology of Huntington's disease are reviewed. Particular interest has been paid to the role of huntingtin and its associated proteins in excitotoxicity mediated via NMDA and kainate receptors.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Brain-Derived Neurotrophic Factor / metabolism
  • Carrier Proteins / metabolism
  • Cell Death
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • DNA-Binding Proteins*
  • Humans
  • Huntingtin Protein
  • Huntington Disease* / genetics
  • Huntington Disease* / metabolism
  • Huntington Disease* / pathology
  • Models, Neurological
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neurons / metabolism
  • Neurons / pathology
  • Neurotoxins / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Oxidative Stress
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Trinucleotide Repeat Expansion

Substances

  • Brain-Derived Neurotrophic Factor
  • Carrier Proteins
  • DNA-Binding Proteins
  • HAP1 protein, human
  • HIP1 protein, human
  • HTT protein, human
  • Huntingtin Protein
  • Nerve Tissue Proteins
  • Neurotoxins
  • Nuclear Proteins
  • Receptors, N-Methyl-D-Aspartate