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Acta Psychiatr Scand. 2001 Nov;104(5):375-9.

Familial occurrence of tardive dyskinesia.

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1
Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.

Abstract

OBJECTIVE:

Familial occurrence of tardive dyskinesia (TD) and schizophrenia has been hypothesized to confer risk to the development of TD. We investigated these hypotheses in a large patient sample applying standardized methods for phenotype characterization.

METHOD:

Two hundred and twenty-two patients with a diagnosis of schizophrenia or schizoaffective disorder were assessed for TD and for family history of schizophrenia or schizoaffective disorder. Thirty-nine patients had 40 affected first-degree family members, one patient having two first-degree relatives. Of these, 17 pairs and one triplet were personally examined.

RESULTS:

1) There was a tendency for TD in the affected relatives to be associated with the TD status of the index-patient; this finding was unrelated to age and doses of neuroleptic medication. 2) No association between a family history of schizophrenia or schizoaffective disorder and TD was found.

CONCLUSION:

A family history of TD might represent a risk factor for TD, whereas a family history of schizophrenia does not.

PMID:
11722319
[Indexed for MEDLINE]
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