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Bioorg Med Chem Lett. 2001 Dec 17;11(24):3119-22.

Two novel cytotoxic and antimicrobial triterpenoids from Pseudolarix kaempferi.

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Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, 200031, Shanghai, PR China.


Two novel antimicrobial and cytotoxic triterpenoids, isopseudolarifuroic acids A (1) and B (2), were isolated from the bark of Pseudolarix kaempferi. The structural elucidation of two novel compounds was carried out mainly by spectroscopic methods, and also by computer modeling. Compounds 1 and 2 exhibited significant cytotoxic activities against several tumor cell lines. Compound 1 also showed most potent antimicrobial activities against both Gram-positive and Gram-negative bacteria.

[Indexed for MEDLINE]

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