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Bioorg Med Chem Lett. 2001 Dec 17;11(24):3099-102.

Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, RY 121-240, PO Box 2000, Rahway, NJ 07065, USA. dooseop_kim@merck.com

Abstract

A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.

PMID:
11720851
DOI:
10.1016/s0960-894x(01)00654-0
[Indexed for MEDLINE]

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