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Curr Issues Mol Biol. 2001 Oct;3(4):91-7.

Synonymous codon usage in bacteria.

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The Institute for Genomic Research, Rockville, MD 20850, USA.


In most bacteria, synonymous codons are not used with equal frequencies. Different factors have been proposed to contribute to codon usage preference, including translational selection, GC composition, strand-specific mutational bias, amino acid conservation, protein hydropathy, transcriptional selection and even RNA stability. The review discusses these factors and their contribution to bias in synonymous codon usage in bacterial genomes.

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