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Trends Cell Biol. 2001 Dec;11(12):466-70.

Integrin signaling revisited.

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Dept. of Vascular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.


Adhesion to the extracellular matrix (ECM) is a crucial regulator of cell function, and it is now well established that signaling by integrins mediates many of these effects. Ten years of research has seen integrin signaling advance on many fronts towards a molecular understanding of the control mechanisms. Most striking is the merger with studies of other receptors, the cytoskeleton and mechanical forces within the general field of signaling networks.

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