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Am J Obstet Gynecol. 2001 Nov;185(5):1068-72.

The effects of hypoxia and hyperoxia on fetal-placental vascular tone and inflammatory cytokine production.

Author information

1
Division of Maternal-Fetal Medicine, Madigan Army Medical Center, Fort Lewis, Wash, USA.

Abstract

OBJECTIVE:

To determine the effects of fetal hypoxia and hyperoxia on placental vascular tone and production of interleukin-6 and tumor necrosis factor-alpha.

STUDY DESIGN:

The maternal and fetal circulation of 2 cotyledons from 5 human placentas were perfused for 4 hours. The fetal circulation of 1 cotyledon was perfused with hypoxic Hanks' balanced salt solution; the other was perfused with hyperoxic Hanks' balanced salt solution. Fetal vascular pressures were recorded every 10 minutes, and fetal vein effluents were collected hourly.

RESULTS:

Fetal-placental vascular perfusion pressure was reduced from baseline during hypoxic conditions. Cytokine concentrations were elevated during hyperoxic conditions compared with hypoxic conditions, with significant differences achieved at 2, 3, and 4 hours for interleukin-6 and at 4 hours for tumor necrosis factor-alpha.

CONCLUSION:

Fetal-placental vasodilation may be a compensatory mechanism to improve hypoxic conditions. Supraphysiologic oxygenation may contribute to the fetal inflammatory response syndrome and to the development of cerebral palsy.

PMID:
11717635
DOI:
10.1067/mob.2001.117636
[Indexed for MEDLINE]

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