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Curr Opin Pediatr. 2001 Aug;13(4):373-5.

Ectopic cardiac calcification associated with hyperparathyroidism in a boy with hypophosphatemic rickets.

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Department of Pediatrics, Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA.


An adolescent with hypophosphatemic rickets developed cardiac calcifications in the absence of hypercalcemia or elevation of the phosphocalcic product (the product of the total serum calcium and phosphorus concentrations). Cardiac calcifications led to aortic and mitral valve dysfunction, myocardial calcification, and arrhythmia. Hyperparathyroidism probably played a significant role in the development of this complication, which emphasizes the necessity for intermittent assessment of parathyroid status in individuals receiving medical therapy for hypophosphatemic rickets.

[Indexed for MEDLINE]

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