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Nat Rev Genet. 2001 Nov;2(11):869-78.

The many roles of an RNA editor.

Author information

1
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

Abstract

The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.

PMID:
11715042
DOI:
10.1038/35098584
[Indexed for MEDLINE]

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