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Psychopharmacologia. 1975;41(3):237-44.

The interaction of post-weaning housing conditions and prenatal drug effects on behaviour.


Offspring of rats given oral doses of imipramine (5 mg/kg) from 14-2f gestation were reared, after weaning, in deprived or enriched environments. When tested in both a Henderson-type maze and a swimming maze no behavioural effects due to prenatal drug exposure were observed when the Ss were reared in a deprived environment. When the Ss were reared in an enriched environment the maze performance of those animals which had been exposed to imipramine or vitamin-A was significantly inferior to that of the control animals. The implications of these findings are discussed with respect to environmental interaction with prenatal drug effects on behavior.

[Indexed for MEDLINE]

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