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J Microbiol Methods. 2001 Dec;47(3):257-72.

Applications of DNA microarrays in microbial systems.

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E328/148B, DuPont Experimental Station, DuPont Central Research and Development, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA.


DNA microarray technology allows a parallel analysis of RNA abundance and DNA homology for thousands of genes in a single experiment. Over the past few years, this powerful technology has been used to explore transcriptional profiles and genome differences for a variety of microorganisms, greatly facilitating our understanding of microbial metabolism. With the increasing availability of complete microbial genomes, DNA microarrays are becoming a common tool in many areas of microbial research, including microbial physiology, pathogenesis, epidemiology, ecology, phylogeny, pathway engineering and fermentation optimization.

[Indexed for MEDLINE]

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