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Cancer Causes Control. 2001 Nov;12(9):855-63.

Body size and ovarian cancer: case-control study and systematic review (Australia).

Author information

1
Queensland Institute of Medical Research, Herston, Australia. davidP@qimr.edu.au

Abstract

OBJECTIVE:

Although increased body mass is an established risk factor for a variety of cancers, its relation with cancer of the ovary is unclear. We therefore investigated the association between measures of body mass index (BMI) and ovarian cancer risk.

METHODS:

Data from an Australian case-control study of 775 ovarian cancer cases and 846 controls were used to examine the association with BMI. We have also summarized the results from a number of other studies that have examined this association.

RESULTS:

There was a significant increased risk of ovarian cancer with increasing BMI, with women in the top 15% of the BMI range having an odds ratio (OR) of 1.9 (95% confidence interval (CI), 1.3-2.6) compared with those in the middle 30%. Stratifying by physical activity showed a stronger effect among inactive women (OR = 3.0, 95% CI 1.3-6.9). The overall effect was consistent with the findings of most prior population-based case-control studies, while cohort studies reported positive effects closer to the null. Hospital-based studies gave variable results.

CONCLUSIONS:

Taken together, the evidence is in favor of a small to moderate positive relation between high BMI and occurrence of ovarian cancer.

PMID:
11714114
DOI:
10.1023/a:1012267619561
[Indexed for MEDLINE]

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