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Nucleic Acids Res. 2001 Nov 15;29(22):4633-42.

REPuter: the manifold applications of repeat analysis on a genomic scale.

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Faculty of Technology, University of Bielefeld, PO Box 10 01 31, D-33501 Bielefeld, Germany.


The repetitive structure of genomic DNA holds many secrets to be discovered. A systematic study of repetitive DNA on a genomic or inter-genomic scale requires extensive algorithmic support. The REPuter program described herein was designed to serve as a fundamental tool in such studies. Efficient and complete detection of various types of repeats is provided together with an evaluation of significance and interactive visualization. This article circumscribes the wide scope of repeat analysis using applications in five different areas of sequence analysis: checking fragment assemblies, searching for low copy repeats, finding unique sequences, comparing gene structures and mapping of cDNA/EST sequences.

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