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J Med Chem. 1975 May;18(5):482-6.

Synthesis and study of glutaryl-S-(omega-aminoalkyl)-L-cysteinylglycines as inhibitors of glyoxalase I.

Abstract

Glutaryl-S-(8-aminooctyl)-L-cysteinylglycine and glutaryl -S-(10-aminodecyl)-L-cysteinylglycine have been prepared by a seven-step procedure as potential ligands for affinity chromatography purification of mouse liver glyoxalase I. Both compounds exhibited nonlinear, mixed-type inhibition of the enzyme. The decyl derivative was a more effective inhibitor than was the octyl analog.

PMID:
1171239
[Indexed for MEDLINE]

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