Format

Send to

Choose Destination
Neurosci Lett. 2001 Nov 23;315(1-2):29-32.

Sleep deprivation elevates plasma corticosterone levels in neonatal rats.

Author information

1
Neurosciences Program, Department of Biological Sciences, School of Medicine, Stanford University, Stanford, CA 94305-5020, USA. Ilana.Hairston.edu

Abstract

Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24. There was an age-dependent increase in basal CORT levels and sleep deprivation significantly elevated CORT at all ages compared to non-sleep deprived controls. The levels of CORT after sleep deprivation in P16, P20 and P24 animals were similar, resulting in an age-dependent decrease of the magnitude of the response. Sleep deprived P12 animals had lower levels of CORT. However, the observed response to sleep deprivation suggests that sleep loss is a significant stressor at this age. These observations suggest that younger animals are more sensitive to the effects of mild sleep deprivation than older ones.

PMID:
11711207
DOI:
10.1016/s0304-3940(01)02309-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center