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Antimicrob Agents Chemother. 2001 Dec;45(12):3657-9.

Inhibition of herpes simplex virus reactivation by dipyridamole.

Author information

1
Division of Neurology and Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. rtenser@psu.edu

Abstract

Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinase-negative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivation-enhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.

PMID:
11709364
PMCID:
PMC90893
DOI:
10.1128/AAC.45.12.3657-3659.2001
[Indexed for MEDLINE]
Free PMC Article

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