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Antimicrob Agents Chemother. 2001 Dec;45(12):3603-6.

Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan.

Author information

1
Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan. muratani@med.uoeh-u.ac.jp

Abstract

We have previously reported that the Neisseria gonorrhoeae isolates from clinical failure cases treated with cefdinir and aztreonam, beta-lactams exhibited high MICs. These resistant isolates were clearly separated from the isolates exhibiting a low level of resistance to beta-lactams as shown by the MIC distribution of cefozopran. Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread.

PMID:
11709349
PMCID:
PMC90878
DOI:
10.1128/AAC.45.12.3603-3606.2001
[Indexed for MEDLINE]
Free PMC Article

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