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Dev Cell. 2001 Nov;1(5):590-2.

Regulated intramembrane proteolysis takes another twist.

Author information

1
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.

PMID:
11709178
DOI:
10.1016/s1534-5807(01)00081-8
[Indexed for MEDLINE]
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