Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13850-3. Epub 2001 Nov 13.

CD5 expression by B lymphocytes and its regulation upon Epstein-Barr virus transformation.

Author information

1
Department of Pathology, Case Western Reserve University, Biomedical Research Building, Room 926, 2109 Adelbert Road, Cleveland, OH 44106-4943, USA. drk5@po.cwru.edu

Abstract

Dim expression of CD5 on human B lymphocytes has been used to delineate B1 and B2 subsets. Nevertheless, others have suggested that the molecule is an activation marker and does not predicate a subset distinction. We have used enzymatic amplification staining, a technology that enhances the resolution of flow cytometric analysis of cell surface molecules by as much as 100-fold, to determine that essentially all human B cells express CD5. Furthermore, we show that this expression is regulated during Epstein-Barr virus transformation.

PMID:
11707593
PMCID:
PMC61130
DOI:
10.1073/pnas.241509398
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center