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Vet Parasitol. 2001 Nov 22;101(3-4):249-60.

A pivotal role for glycans at the interface between Trichinella spiralis and its host.

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James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.


The nematode Trichinella spiralis demonstrates a simple but novel parasitic life-cycle, completing all of its development in intracellular habitats. This feature of the life-cycle has challenged investigators aiming to elucidate mechanisms of parasitism. Investigations of immunity showed a dominant influence of N-glycans in the responses to larval T. spiralis. It has become evident that novel glycans are positioned to play important roles in parasitism, as well as immunity, in infection with this nematode.

[Indexed for MEDLINE]

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