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FEBS Lett. 2001 Nov 9;508(1):143-8.

In silico screening for tumour-specific expressed sequences in human genome.

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Vavilov Institute of General Genetics, 3 Gubkina Str., Moscow 119991, Russia.


A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.

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