Format

Send to

Choose Destination
J Photochem Photobiol B. 2001 Nov 1;64(1):1-7.

Photosensitizing properties of a boronated phthalocyanine: studies at the molecular and cellular level.

Author information

1
Molteni Farmaceutici, S.S 67 Loc. Granatieri - 50018 Scandicci, Florence, Italy. jorilab1@civ.bio.unipd.it

Abstract

A synthetic procedure has been developed for the preparation of a Zn-phthalocyanine peripherally substituted with a dodecaborane. The absorption spectrum of the derivative is typical of the phthalocyanine chromophore. Moreover, the boronated phthalocyanine exhibits a high photosensitizing efficiency against a model biological substrate, such as N-acetyl-L-tryptophanamide, and a singlet oxygen quantum yield of 0.53 in dimethylformamide. Even though the presence of the dodecaborane moiety appears to decrease the affinity of the phthalocyanine for HT-1080 transformed human fibroblasts, the boronated phthalocyanine causes an essentially complete loss of cell viability upon irradiation with 600-700 nm light under mild conditions (1 microM concentration, 5-min irradiation at 10 mW/cm(2)).

PMID:
11705724
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center