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J Neurovirol. 2001 Dec;7(6):564-9.

Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system.

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August Kirchenshtein Institute of Microbiology and Virology, University of Latvia, Ratsupites st. 1, Riga LV-1067, Latvia.


Peripheral blood mononuclear cells and plasma of 113 patients with neurological disorders and 150 blood donors were analyzed for HHV-6 and HHV-7 sequences by PCR. The prevalence of HHV-6 was significantly higher in patients with multiple sclerosis (P < 0.01) than in cases of nondemyelinating diseases of the central and demyelinating diseases of the peripheral nervous systems and blood donors. HHV-6 viremia was found only in patients with multiple sclerosis, predominantly in the active phase of the disease. A significantly higher frequency of HHV-7 reactivation in patients with demyelinating diseases of the peripheral nervous system suggests also its association with demyelinating processes.

[Indexed for MEDLINE]

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