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Fertil Steril. 2001 Nov;76(5):936-42.

In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome.

Author information

1
McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. timothychild@yahoo.com

Abstract

OBJECTIVE:

To investigate differences in immature oocyte maturation, fertilization, and pregnancy rates among women with unstimulated normal ovaries, polycystic ovaries (PCOs), or PCOS.

DESIGN:

Prospective observational study.

SETTING:

University fertility clinic.

PATIENT(S):

One hundred forty-four women undergoing 180 in vitro oocyte maturation treatment cycles.

INTERVENTION(S):

Transvaginal immature oocyte recovery from unstimulated ovaries 36 hours after hCG priming. In vitro oocyte maturation and fertilization. Fresh embryo transfer.

MAIN OUTCOME MEASURE(S):

Immature oocytes collected, metaphase II oocytes, and embryos produced. Implantation and pregnancy rates.

RESULT(S):

The overall oocyte maturation and fertilization rates attained were 80.3% (1,222 of 1,522) and 76.5% (935 of 1,222), respectively. Significantly fewer immature oocytes were retrieved from normal ovaries (5.1 +/- 3.7) compared with the PCO (10.0 +/- 5.1) or PCOS (11.3 +/- 9.0) groups. Fertilization and cleavage rates were comparable among the three groups. The implantation, pregnancy, and live birth rates per transfer for normal ovaries were 1.5%, 4.0%, and 2.0%, respectively; for PCOs 8.9%, 23.1%, 17.3%, respectively; and for women with PCOS 9.6%, 29.9%, and 14.9%, respectively.

CONCLUSION(S):

Immature oocytes retrieved from normal ovaries, PCOs, or women with PCOS, when using hCG priming before oocyte retrieval, have a similarly high maturation, fertilization, and cleavage potential. In vitro maturation is a useful treatment option, particularly for women with PCOs.

PMID:
11704114
DOI:
10.1016/s0015-0282(01)02853-9
[Indexed for MEDLINE]

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