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Science. 2001 Nov 9;294(5545):1299-304.

The guanine nucleotide-binding switch in three dimensions.

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1
Max-Planck-Institut für Molekulare Physiologie, 44227 Dortmund, Germany.

Abstract

Guanine nucleotide-binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states. Recent structural studies show that the switch apparatus itself is a conserved fundamental module but that its regulators and effectors are quite diverse in their structures and modes of interaction. Here we will try to define some underlying principles.

PMID:
11701921
DOI:
10.1126/science.1062023
[Indexed for MEDLINE]
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