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Trends Biochem Sci. 2001 Nov;26(11):679-84.

The hunchback and its neighbours: proline as an environmental modulator.

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Affitech AS, Oslo Research Park, Gaustadalléen 21, N-0349, Oslo, Norway.


The unique ability of Pro or Pro-rich repeats to affect the stability and function of proteins has recently been highlighted by biophysical studies on fragments from prions, signalling domains and muscle proteins. Pro-rich regions have been observed to either occupy disordered states or adopt various helical structures; some are also able to undergo an environmental-dependent transformation between these states. Such a transformation could explain some of the inherent functional properties of the parent proteins and, additionally, can be efficiently exploited to generate novel temperature- and pH-switches in more conventional globular proteins.

[Indexed for MEDLINE]

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