Calcium alginate microspheres of Bacillus subtilis

Drug Dev Ind Pharm. 2001 Sep;27(8):825-9. doi: 10.1081/ddc-100107246.

Abstract

Microspheres of Bacillus subtilis were prepared using sodium alginate. Some typical properties of microencapsulated systems, such as microorganism content, particle size, and germination time, were studied. Calcium alginate microspheres were obtained by the emulsification method, dripping into a solution of calcium salt. The conditions of the preparation steps were very soft to produce calcium alginate microspheres containing cells with no apparent changes in general biological properties. The hydrogel matrix provides protection without preventing communication with the surrounding medium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alginates / chemistry*
  • Bacillus subtilis* / growth & development
  • Colony Count, Microbial
  • Drug Compounding
  • Emulsions
  • Excipients
  • Microscopy, Electron, Scanning
  • Microspheres
  • Particle Size

Substances

  • Alginates
  • Emulsions
  • Excipients