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Curr Opin Cell Biol. 2001 Dec;13(6):748-53.

Putting the stress on senescence.

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Department of Immunology and Oncology, National Center of Biotechnology (CSIC), Campus de Cantoblanco, Madrid E-28049, Spain.

Erratum in

  • Curr Opin Cell Biol 2002 Feb;14(1):123.


Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicative senescence'. Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.

[Indexed for MEDLINE]

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