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FEBS Lett. 2001 Nov 2;507(3):357-61.

Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes.

Author information

1
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, G12 8QQ, Glasgow, UK. l.chamberlain@bio.gla.ac.uk

Abstract

Lovastatin treatment caused down-regulation of the insulin-responsive glucose transporter 4 (Glut4) and up-regulation of Glut1 in 3T3-L1 adipocytes. These changes in protein expression were associated with a marked inhibition of insulin-stimulated glucose transport. Lovastatin had no effect on cell cholesterol levels, but its effects were reversed by mevalonate, demonstrating that inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. These findings support the notion that whole body insulin resistance may arise as a result of perturbations in general biochemical pathways, rather than primary defects in insulin signalling.

PMID:
11696371
DOI:
10.1016/s0014-5793(01)03007-1
[Indexed for MEDLINE]
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