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Lik Sprava. 2001 Jul-Aug;(4):181-2.

[Role of cytokines in the metabolism of the extracellular matrix carbohydrate-protein components in patients of various ages with gastroduodenal ulcer].

[Article in Ukrainian]

Abstract

The results of the study made in 43 patients with gastroduodenal ulcer have shown an increase in the production of proinflammatory cytokines (interleukin-1 beta, the tumor necrosis factor-alpha) and a decrease in the blood serum content of the transforming growth factor-beta, which events come to favour degradation processes in collagen and fucoglycoproteins with a concomitant increase in free oxyproline, serum protein-unbound fucose against the background of a suppressed synthesis of the extracellular matrix carbohydrate-protein components as evidenced by the serum diminished concentrations of protein-bound oxyproline and fucose, hexuronic acids, and hexosamines.

PMID:
11692712
[Indexed for MEDLINE]

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