Abstract
The average 50% inhibitory concentration (IC(50)) values for AD169 were 0.22 +/- 0.09 microM 1263W94 and 5.36 +/- 0.12 microM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC(50) was 0.42 +/- 0.09 microM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC(50) was 3.78 +/- 1.62 microM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-HIV Agents / pharmacology*
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Antiviral Agents / pharmacology*
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Benzimidazoles / pharmacology*
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Cytomegalovirus / drug effects*
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Cytomegalovirus / genetics
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DNA, Viral / analysis
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Fibroblasts / virology
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Flow Cytometry
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Ganciclovir / pharmacology*
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Humans
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Inhibitory Concentration 50
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Nucleic Acid Hybridization
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Ribonucleosides / pharmacology*
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Viral Plaque Assay
Substances
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Anti-HIV Agents
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Antiviral Agents
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Benzimidazoles
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DNA, Viral
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Ribonucleosides
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Ganciclovir
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maribavir