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Respir Res. 2001;2(5):269-72. Epub 2001 Jul 12.

Tumor necrosis factor-alpha and muscle wasting: a cellular perspective.

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Pulmonary Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.


Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-alpha on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-alpha disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-kappaB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-alpha effects on skeletal muscle and the mechanism of TNF-alpha action.

[Indexed for MEDLINE]
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