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Respir Res. 2001;2(2):61-3. Epub 2001 Feb 21.

Autoantibodies in cryptogenic fibrosing alveolitis.

Author information

1
Royal Brompton Hospital, Sydney Street, London, UK.

Abstract

The pathogenesis of cryptogenic fibrosing alveolitis (CFA) involves injury, an immune/inflammatory response and fibrosis. The cause of the injury is unknown, but the identification of serum autoantibodies makes an autoimmune aetiology attractive. The core study on which this commentary is based used novel cloning and serum screening technologies in order to identify new public and private autoantibodies in sera from 12 patients with CFA. Largely negative conclusions were drawn from that study. However, we suggest that the prevalence of autoantibodies may have been underestimated, that the study was timely and that this approach is worth pursuing further.

PMID:
11686865
PMCID:
PMC59568
DOI:
10.1186/rr38
[Indexed for MEDLINE]
Free PMC Article

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