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Am J Kidney Dis. 2001 Nov;38(5):1108-12.

Rhabdomyolysis, acute renal failure, and death after monensin ingestion.

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Division of Nephrology, Intensive Care Unit, Service of Toxicology, and Department of Pathology, Hospital de Base, São José do Rio Preto Medical School, São José do Rio Preto, SP, Brazil.


We report a case of human monensin intoxication; to our knowledge, this is the first reported case in the medical literature. The patient took a dose of monensin three times higher than a dose considered lethal for cattle and developed a clinical picture similar to that reported in veterinary medicine. There was an early and extremely severe rhabdomyolysis followed by acute renal failure, heart failure, and death. The main changes observed at autopsy were extensive skeletal muscle necrosis, complement deposition at the myocardial level, pulmonary edema, and acute tubular damage.

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